美国出台计划对抗老年痴呆症(2/2)
概述：上周，美国政府宣布了一项对抗阿尔茨海默氏病的重大教育研究活动，希望该计划能给痴呆症患者带来福音。Hints:
Medellin
Colombia
Alzheimer's
crenezumab
placebo
Pierre Tariot
mid-40s
注意说话人转述时加单引号~~
校对：雨尽无言
翻译：Olivertt
注解：Olivertt
组长：莜珍
答疑：大爱柯南http://t1.g.hjfile.cn/listen/201205/201205281057428662748.mp3The study will involve members of a large extended family living in villages in the Medellin area of Colombia. Some of the family members have a rare genetic disorder that causes them to get early-onset Alzheimer's. They begin to show signs of mental loss in their mid-40s and fully develop the disease by their early 50s.
300 people have agreed to be in the study. 1/3 of them will receive crenezumab. The others will be given a placebo, a pill that does not contain any drug. They will not know if they have been given the drug or the placebo. The study will also include a smaller number of people in the United States.
Pierre Tariot will help lead the study, known as a human trial. He says all of the people have been informed that the drug might not work or that they might receive a placebo. Mr. Tariot says the people still wanted to be in the study.
"They have been faced with this devastating illness hitting every generation for hundreds of years. As one of them put it, 'There are many rivers to cross but at least we're at the first bank.' And that's kind of the attitude that people have had."
Scientists hope that if the drug works in those facing early-onset Alzheimer's, then it might also help older people.
The study in Colombia could take as long as five years, but researchers believe they could get results in two years.这项研究将涉及到居住在哥伦比亚麦德林地区多个村庄中的一个大家族的成员。这个家族的一些成员患有罕见的遗传性疾病，该病会导致他们患上早发型阿尔茨海默氏症。他们会在40岁中期开始有智力丧失的迹象，50岁早起就彻底患上此病。
已经有300人同意参与此项研究。其中三分之一的人将接受crenezumab药物治疗。其他人将服用安慰剂，即一种不含任何药物成分的药片。他们本人并不知道自己服用的是药物还是安慰剂。该项研究还包括一小部分美国人。
皮埃尔·塔里奥将主导这项被称为人体试验的研究。他说，所有参与研究的人都已被告知药物可能不起作用，或者他们服用的可能只是安慰剂。塔里奥称，即便如此他们也希望参与到研究中来。
“数百年来，他们的每一代人都面临着这项毁灭性的疾病。正如其中一人所言，‘虽然要过很多道坎，但至少我们在最前面’。并且他们已经抱有这种态度。”
科学家们希望，如果这种药物对早发型阿尔茨海默氏症患者有效，则它对病程较深的患者也有效。
这项在哥伦比亚进行的研究可能需要5年时间，但是研究人员认为他们可以在两年内得出结果。
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