小孩子脏一点没关系(2/2)
一项新的研究发现，对细菌的接触可以增强人的抵抗力。也就是说，小孩子弄脏一点反而有助于以后的身体健康。Hints:
Dr. Blumberg
killer T cells
asthma
ulcerative colitis
Rob Dunn
North Carolina State University
Raleigh
Science
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组长：李奇亮
答疑：trans0829http://t1.g.hjfile.cn/listen/201204/20120406095740206947.mp3Now, Dr. Blumberg and a team have what they say is the first biological evidence to link early exposure to germs to stronger adult immune systems. They say this exposure could prevent the development of some autoimmune diseases.
In the adult germ-free mice, they found that inflammation in the lungs and colon was caused by so-called killer T cells. These normally fight infection. But they became overactive and targeted healthy tissue -- an autoimmune condition seen in asthma and a disease called ulcerative colitis.
Dr. Blumberg says the mice raised in a normal environment did not have the same reaction. He says their immune systems had been "educated" by early exposure to germs.
Rates of autoimmune disorders are rising worldwide, but mostly in wealthier, industrialized countries.
"I think one obvious question, for example, that's raised by these studies is the early life use of antibiotics and whether we need to be more careful in their prescribing."
Rob Dunn is a professor of ecology and evolutionary biology at North Carolina State University in Raleigh. He says the new study does not mean people should stop washing.
"Wash your hands, but don't do it with antimicrobial soap. Let your kids play in a reasonable amount of dirt and get outside and get exposed to a diversity of things."
The study appears in the journal Science.目前，布伦伯格博士及团队获得了他们所说的第一份生物证据，该证据将儿童时代的细菌接触活动与成年人免疫系统的增强联系了起来。他们表示，这种接触可以防止某些自身免疫性疾病的发展。
在成年无菌鼠身上，他们发现肺部和结肠的炎症是所谓的杀手T细胞引起的。杀手T细胞通常对抗感染，但它们变得过度活跃就会针对健康组织，也就是哮喘和溃疡性结肠炎中可以看到的自身免疫状况。
布伦伯格博士表示，在正常环境下长大的小鼠没有同样的反应，它们的免疫系统已经经历过早期接触细菌的“洗礼”。
全球范围内，自身免疫性疾病的比例正在不断上升，但主要发生在富裕的工业化国家。
“我认为这些研究提出的一个明显的问题就是，在生命早期使用抗生素是否合理，以及我们是否需要更在开处方时更加谨慎。”
罗布·邓恩是位于罗利市的北卡罗来纳州立大学的一名生态学及进化生物学教授。他说，这项新研究并不意味着人们应当停止清洗身体。
“在洗手时不要使用抗菌肥皂。让您的孩子在适量的灰尘中玩耍，到户外去，去接触各种各样的事物。”
该研究发表在《科学》杂志上。
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